I am on that treatment. No side effects at all (hearing is fine no tintinitus). I was unable to take Tobi and was on Merem IV and now I'm on Sodium Chloride 3% plus the Azithro (250 mg) 3 times a week. (also Breo and Albuteral PRN) I have only been on this treatment since December but so far no downside. People on here say though that it can cause resistance (MAC etc.) but I guess that is a risk one has to decide to take. I haven't had a relapse but what means I don't know!