I'm 64 and have been taking hydrocodone 10/325 for about 20 years. I take them every 7 hours. My script says every 6 and every now and then I need them every 4 hours but maybe only 2 times a month. They still work as well as when I started taking them. I do not have a problem with constipation. I also was worried about the overdosing but I believe if you take them for what they intended for then it's not a problem. Just because it says take every 6 doesn't mean to do so. I went to every 7 just to see if I could tell a difference or the pain was there before the 7 hours. I have Dr. appt today, moved from last Monday because I had too many pills left, and I still have enough for about 5 days. I'll go and they'll just fill one and put the other on my file for later and when I need it, I'll call. I'm not worried about overdosing because I'll never take enough for that to happen. One is almost out of my system by the time I take another. They keep me functioning and that's what counts. I did hair for 30 years and my back and neck are paying the price.