My own (nonmedical ) feeling about PPIs is quite negative. They seemed to be as hard to get off of as opiates. The Peoples Pharmacy has a good "tea" you can make to help the rebound effect and the heartburn. H2 blockers are milder and much preferred. I think doctors are much too quick to perscribe them. That being said, they do have their place. I had to cure a horse with gastritis and it did the trick. But with him, I could dictate the taper. People are not so compliant.