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@jmh22

ESR1 is a mutation selected by use of aromatase inhibitors so its good that you don't have that. BC cells with e-cadherin mutation (majority of lobular) may respond to ROS1 inhibitors like crizotinib (currently approved for NSC lung cancer and being studied for lobular carcinoma). They are or will soon be finished with recruitment for the study in the UK and hopefully data will be reported soon. Study of a different ROS1 inhibitor will be starting in the US soon. Just looking forward to agents targeting lobular carcinoma.

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Replies to "ESR1 is a mutation selected by use of aromatase inhibitors so its good that you don't..."

I’m so sorry you are going through this! I was diagnosed with stage 4 metastatic lobular carcinoma a year ago and had a bi-lateral mastectomy last November. Finished chemo last month and headed to radiation in 2 weeks. This is an insidious disease because it usually not detected until it’s stage 3 or 4. It’s been a very rough road though while the physical part is destructive to the body, the mental and emotional “side effects” can be just as devastating. It can be difficult to do, that’s for sure, find your center and try to remain grounded in that. Best to you!