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@michaele74

I See Oncologist 5/19. All the tests are to determine what might work. Looks like no chemo from your experience. My sclerotic lesions May still be microscopic. Just found as on 4/26 after bilateral mastectomy. I plan to discuss with doctor. Had surgery at UC San Diego. Now at Cancer Care Northwest in Spokane, Washington. The Kisqali and Fulvestrant will be an attempt at estrogen blocking. Have had DNA testing but not sure if I have the e- cadherin mutation. Is that ESR1 mutation? I did not have ESR1 and could not take new elacestrant pill and they are recommending the Fulvestrant injection.

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Replies to "I See Oncologist 5/19. All the tests are to determine what might work. Looks like no..."

ESR1 is a mutation selected by use of aromatase inhibitors so its good that you don't have that. BC cells with e-cadherin mutation (majority of lobular) may respond to ROS1 inhibitors like crizotinib (currently approved for NSC lung cancer and being studied for lobular carcinoma). They are or will soon be finished with recruitment for the study in the UK and hopefully data will be reported soon. Study of a different ROS1 inhibitor will be starting in the US soon. Just looking forward to agents targeting lobular carcinoma.