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DiscussionAnyone with invasive lobular cancer stage 4 that has metastasized?
Breast Cancer | Last Active: Jun 8, 2023 | Replies (25)Comment receiving replies
Replies to "I See Oncologist 5/19. All the tests are to determine what might work. Looks like no..."
ESR1 is a mutation selected by use of aromatase inhibitors so its good that you don't have that. BC cells with e-cadherin mutation (majority of lobular) may respond to ROS1 inhibitors like crizotinib (currently approved for NSC lung cancer and being studied for lobular carcinoma). They are or will soon be finished with recruitment for the study in the UK and hopefully data will be reported soon. Study of a different ROS1 inhibitor will be starting in the US soon. Just looking forward to agents targeting lobular carcinoma.