My rheumatologist seemed to feel that Kevzara and Actemra were similar and that it did not matter which was used as I taper off Prednisone. Both suppress the IL-6 immune system pathway. I'm on Actemra only because my medical provider gets it more cheaply, so they prefer its use. My guess is that the Kevzara side effects are far less than Prednisone; Kevzara is highly targeted and is not a hormone, so likely tolerated far better than Prednisone.