Yes, Methlttexate does have so many risks. They want me to take it instead of my pain medication and sorry I am not willing to give up what works just because of the Opiod Crises. Many people do well on Hydrocodone and I am one who does have any issues except DR’s all but for forcing me off. Doctors are trying to force patients off something onto something in my opinion could be more dangerous. No one can dictate you need to suffer. I’m my best advocate for sure.