Not sure what long term means. I was prescribed and hesitate but my doctor at the time said “we don’t worry about use until the one year mark.” I was I going to do it beyond a year. At 6 months, not feeling a lot better, I went back to my doctor. She had retired and the new doctor listened to me and contacted GI. Within two days I was scheduled for an endoscopy. Afterwards, the GI came in and told me to never take a PPI again. My digestive cells had become hypertrophic (enlarged). That was the point where I had had it with prescription drugs treating only my symptoms for a number of years. I turned to Functional Medicine, where the goal is to find the cause or causes of symptoms. I found an exceptional doctor and finally feel I’m healing.