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Has anyone taken the targeted therapy osimertinib (Tagrisso)?

Lung Cancer | Last Active: Jun 16 6:00pm | Replies (139)
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@lls8000

Hi @gavinmyers13, Have you seen this recent discussion from other EGFR patients too? https://connect.mayoclinic.org/discussion/newly-diagnosed-lung-cancer-egfr-mutation-stage4/?pg=2
Most of the Tyrosine kinase inhibitors (TKIs) are tolerated fairly well. The doctors will likely want to monitor liver and kidneys early on, and there are commonly GI related side effects. These meds have been life saving for many of us. I take a different TKI specific to ALK Positive lung cancer, also metastatic (diagnosed in 2020). I’m hopeful that the treatment will be effective for your mother too.
How is she feeling? Is she experiencing symptoms?

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Replies to "Hi @gavinmyers13, Have you seen this recent discussion from other EGFR patients too? https://connect.mayoclinic.org/discussion/newly-diagnosed-lung-cancer-egfr-mutation-stage4/?pg=2 Most of..."
gavinmyers13 | @gavinmyers13 | May 12, 2023

Thanks, Lisa! I'll check that discussion out. I'm thinking we need to know specifics on my mom's mutation as we haven't been told exactly what her's is. He has shared that it is likely her cancer develops a resistance to this Tagrisso, is that common for all mutations or more likely just for my mom's, do you know?

Thankfully she is physically doing quite well. We discovered her cancer from her suddenly sensing numbness in her lower body and a mysterious bladder issue. After a couple of months of her doctor and some specialists scratching their heads a neurologist at Mayo discovered a lesion in her sacrum that is pressing on the nerves controlling her bladder and lower body, then found the primary in her left lung. She had immediate radiation for 5 days on the sacrul lesion and is starting this TKI Tagrisso tomorrow to tackle the left lung lesion and the mets in her brain. Emotionally, it's a rollercoaster but we're taking things one day at a time.

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