Yes, but it does not last too long. She has to get a good sample.

I had a hysteroscopy this past January. I have also had an endometrial biopsy.
The endometrial biopsy was done in the doctor's office when I had post-menopausal bleeding.
I was not given any anaesthesia for this but was advised by a sister who'd had one to take ibuprofen ahead of time. I forgot until I was in the doctor's office. This procedure was quite uncomfortable but not intolerable for me. The uncomfortable part didn't take longer than 5-10 minutes. I was not achey afterward that I can remember.

For the hysteroscopy procedure, I was sedated via IV and remember getting ready for it and waking up in recovery, but never experienced any pain during or after. Only a little spotting afterward. The worst part of this one was that, for some reason, I had to take nothing by mouth for 12 hours prior and this made it difficult for them to find my veins (and I usually give blood and have no problems, as I'm well hydrated then). I felt well cared for by the team and would encourage you to ask for further information about which procedure you'll have and how they will manage pain for you.

Best wishes for minimal discomfort and good news afterward....