As you can see by people's responses, NONE of these medications commonly prescribed for PN actually do much! They are chemicals that the body tolerates but they have side effects and I would guess they are not good for you long term. The bottom line is that they only reduce PN by maybe 10% or so!
My Experience:
Gabapentin - a very old drug that WILL make you sleepy, good as a sleeping pill maybe.
Lyrica - has the side effect of a slightly dizzy feeling, sometimes slight high feeling.
Cymbalta - my experience is that this has the fewest side effects, but also only reduces PN slightly.
CBD - does nothing at all for me
THC - makes you high and also forgetful. Some relief from PN but again maybe 10% less, not worth it.
I stopped taking all of these years ago and depend mostly on getting an hour of hiking (use 2 walking poles) or biking in every other day. I feel better and walk better for hours after exerciseing. I also take 600mg of alpha lipoic acid plus 1000mg of fish oil but again I don't think it is of much help. A strong cup of coffee in the morning seems to help with PN.

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