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Neuropathy + Proton-pump Inhibitor use?? Anyone had this experience?

Neuropathy | Last Active: Apr 28 8:20pm | Replies (35)
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@misu

Hello Steve -- your experience with PPI is interesting, in that I've been taking lowest-possible doses of omeprazole for years but attempts to stop it result in more stomach pain than I'm prepared to tolerate. I'm told it interferes with calcium metabolism, and since I'm small-boned and osteopenic, it worries me that if I ever get a knee replacement it might not go well. The surgeon I saw last week said I wasn't a TKR candidate because of the neuropathy. I'll be following you hoping to learn more.

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Replies to "Hello Steve -- your experience with PPI is interesting, in that I've been taking lowest-possible doses..."
John, Volunteer Mentor | @johnbishop | May 3, 2023

Hello @misu and @stevel3333, Welcome to Connect. Since you were discussing PPIs and neuropathy, I thought I would share a reference I found on the topic in case you haven't seen it.

--- How can proton pump inhibitors damage central and peripheral nervous systems?:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716020/

I've had a knee replacement and also have osteopenia but fortunately I'm not on a PPI. I also have idiopathic small fiber peripheral neuropathy which wasn't affected by having a TKR.

Have you done any research or looked into any alternatives for taking PPIs?

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