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I was diagnosed with stage 3 pancreatic cancer in jan 2021. I have had Whipple surgery with msv reconstruction followed by 12 treatments of Folfirinox. Dietician guidelines for Creon were:
Take 300-1800 units per gram of fat, or 500-2500 units per kg of body weight per meal. Too little Creon results in gas, bloating and diarrhea. Sufficient Creon usually results in darker stools.
I am currently taking 125,000-175,000 units immediately prior to eating a meal with generally good results – no gas, bloating or diarrhea, although still no change in stool colour. I was assured it is almost impossible to overdose on Creon, so to continue to increase until stools darken to normal colour. Recently, they had me try to reduce the amount I was taking but that resulted in gas and diarrhea returning. I have had to adjust dose as I slowly regained weight. Latest discussion indicated stool colour can also be impacted by surgery, so the go more on how I am feeling than colour of stool. All the best to you!

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Replies to "I was diagnosed with stage 3 pancreatic cancer in jan 2021. I have had Whipple surgery..."

Are you taking the Creon all at once or staggering the capsules throughout the duration of the meal as it should be?

The Canadian Digestive Health Foundation has developed a dosing calculator making it easier to determine the amount of capsules necessary for efficient digestion. The calculator is at https://digestthis.ca