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Weaning off of Pristiq

Depression & Anxiety | Last Active: Oct 5, 2025 | Replies (64)

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HI, @geez -- welcome to Mayo Clinic Connect. Thanks for sharing your experience with starting to taper off of Desvenlafaxine Succinate (Pristiq).

Hoping here in this discussion you can meet @betteralready @tspoon @withbecka @safetyshield @beconscious and @gagelle. Thought you'd also like to meet @gman007 and @gailb, Connect volunteer mentors.

You mentioned a brain zap type experience. Wondering if you can share more about that?

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Replies to "HI, @geez -- welcome to Mayo Clinic Connect. Thanks for sharing your experience with starting to..."

Felt like an electric shock to my brain for lack of a better description.