I have been on Annoro for about a year now, it seems to work well for me. You can only take one dose every 24 hrs, and I take mine about 6:30pm or so. I was having trouble sleeping at night because of mucus buildup from my Bronchiectasis, and it helps break up the mucus so I can sleep at night. It still seems to be effective for me until around 6:00am the next morning. I only wish I could take twice a day!!!