Welcome @emtsnts, I don't really know the answer but the following article does mention your question and has some links to studies on the topic.

--- Berberine Shrinks Arterial Plaque, New Study Finds: https://highintensityhealth.com/berberine-shrinks-arterial-plaque-new-study-finds/

There is also this study using mice - Berberine derivatives reduce atherosclerotic plaque size and vulnerability in apoE−/− mice: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261588/.

Can you share what prompted your question? Did you have a discussion with your doctor?

Here's a link about berberine as a supplement that may answer your question.
https://www.webmd.com/vitamins/ai/ingredientmono-1126/berberine