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Low Dose Naltrexone and Prednisone for PMR?

Polymyalgia Rheumatica (PMR) | Last Active: Aug 4 6:29am | Replies (85)
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@pkalkstein

Alas, my good fortune did not last. On the third day of 7.5mg prednisone, I had a flare. I went back to 12.5 mg to calm things down, and am now back at 10mg. From what I understand of the results of others, LDN begins to be efficacious when prednisone

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Replies to "Alas, my good fortune did not last. On the third day of 7.5mg prednisone, I had..."
suetex | @suetex | Apr 29, 2023

Please consider using MSM daily to help prevent relapses. Also helps with some pain. No side effects, look it up..

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pkalkstein | @pkalkstein | May 5, 2023

As reported, LDN did not replace the diminished prednisone, and thus a flare occurred. However, I have raised my LDN dose to 7mg, taken just before bed. This has had several good results. The peripheral neuropathy is gone (but I also upped the B-12, so maybe that was it), and I have now had two nights with no allergy. Since titrating up to 7 I have slept like a log and have not been troubled by weird dreams. I think I have yet to find the LDN "sweet spot" and still have hopes for action against PMR, although that hasn't happened yet.

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