Since everyone reacts to meds differently, it might be worth trying letrozole. You can always stop it if you don't feel the side effects are worth it. I've been taking it for over 2 years, but I've also been taking Kisqali and Octreotide (for a different cancer) at the same time so it's hard for me to pinpoint which side effects are from which med. So far, I've decided all three meds are worth it. Best of luck to you.