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@sueinmn

Both Rifampin/Rifabutin and Azithromycin can cause swelling in the legs due to fluid retention.
If this is a new symptom for you, it should be reported to both your pulmonologist (or ID doc) and your primary care provider. Extra caution is indicated if you have a history of heart problems, high blood pressure or blood clots.
Also, if you have recently had a change in any other medications this could be an other cause.
Sue

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Replies to "Both Rifampin/Rifabutin and Azithromycin can cause swelling in the legs due to fluid retention. If this..."

Thank you Sue, I see my pulmonologist next week and my PC the following week so will followup with them. There are so many side effects from the medications you don't know if it is the pills or something else.