Unfortunately, I have developed gallstones, from Tamoxifen. I can't take any of the other HRTs, because of my osteoporosis. Because I am stage 1, with a Oncotype DX lower than 18, my oncologist told me I could decide to go off of it. I did, and am now taking Indole-3-Carbinol 200mg, and 1000mg, ( the amount is supposed to be at least 3000mg.) Turkey Tail Mushroom capsules. It is very expensive for me on only Social Security. Tamoxifen was $1.30 a month. There is ongoing research regarding both of these substances.