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Great results with Zytiga and Eligard want to put off radiation.

Posted by pianoman @philipbrachko, Apr 16, 2023

I was diagnosed with regional metastatic PC last summer, was put on Zytiga for 6 months and I am still on Eligard. PSA has been

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pianoman | @philipbrachko | Apr 22, 2023
In reply to @jibway "It would seem to me to see how hormone treatment Eligard 45 mg 6 month dose..." + (show)
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It would seem to me to see how hormone treatment Eligard 45 mg 6 month dose would work, tumor still contained in my husband’s prostate, he is 80, before beginning radiation??? Just wonder. All new to us.
Thank you

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I'm only 8 months into this, Eligard and Zytiga and prednisone for 6 mo. Still on Eligard , My testosterone has been

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jibway | @jibway | Apr 24, 2023

Thank you. Did cancer shrink? He had his shot 3 Days ago, go back May 8th for spaceoer then radiation.

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pianoman | @philipbrachko | Apr 25, 2023
In reply to @jibway "Thank you. Did cancer shrink? He had his shot 3 Days ago, go back May 8th..." + (show)
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Thank you. Did cancer shrink? He had his shot 3 Days ago, go back May 8th for spaceoer then radiation.

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Yes my cancer is undetectable , I'm going to put off radiation for as long as I can. Good luck, keep in mind everybody is different. I'm lucky so far.

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jibway | @jibway | Apr 26, 2023
In reply to @philipbrachko "Yes my cancer is undetectable , I'm going to put off radiation for as long as..." + (show)
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Yes my cancer is undetectable , I'm going to put off radiation for as long as I can. Good luck, keep in mind everybody is different. I'm lucky so far.

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We trust these doctors, far above anywhere else. Going with their plan and keeping the faith and trust.

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williemac | @williemac | Nov 28, 2025
In reply to @spryguy "I hope this combination ( Zytiga, Prednisone, Eligard) works. I've been on it for 8 mos...." + (show)
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I hope this combination ( Zytiga, Prednisone, Eligard) works. I've been on it for 8 mos. Side effects from these is "soul crushing" . BUT PSA IS UNDETECTABLE.
The slated course of treatment is 16 additional mos.
GOOD LUCK TO ALL

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@spryguy Can you dive deeper into your comment about it being soul crushing? Did you also have radiation therapy? How are you doing now?

Thanks

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spryguy | @spryguy | Nov 28, 2025

The early process was an abyss of confusion and fear.
That was 3+ years ago.
It was 7 mos until I went to Mayo ( Phoenix). The care I received was a rescue from the abyss.
My treatment plan started with lupron (2.5 yrs) concurrent with radiation (40 sessions) and then
Abiaterone with prednisone for 2 years. Lots of side effects and it is chemo in pill form. Treatment concluded in 2024. (I am now 78) I am in remission and still trying to loose weight and beat the fatigue. I do feel pretty good and slowly getting better. I am optimistic about the future. I hope you are doing OK and have a positive outcome. Good Luck God Bless

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spryguy | @spryguy | Nov 28, 2025
In reply to @spryguy "I started IMRT watching my diet. As time went on I would occasionally eat foods that..." + (show)
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I started IMRT watching my diet. As time went on I would occasionally eat foods that were not advised and toward the end of the 39 sessions I was eating anything I wanted in moderation. I even had pizza and beer once. No ill effects.
My treatment plan going forward is 16 mos of ADT (zytiga prednisone and eligard). In Sept of 2024 all meds to be withdrawn and PSA test every 3 mos.. IF (when) PSA increases to > 0.4 ng/ml. I expect a PSMA pet/ct scan to show some specific locations of recurrence . Those areas can then be treated by the appropriate therapy and then perhaps ADT again.
"Rinse and repeat" until something else takes me out.
"Such is Life"

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@spryguy we are on the same path. All my PSA results have been undetectable . Testosterone is still very low it does increase by small increments.

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heavyphil | @heavyphil | Nov 29, 2025
In reply to @philipbrachko "Again thanks for the reply, I did have the PSMA/CT scan. I had it in August,..." + (show)
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Again thanks for the reply, I did have the PSMA/CT scan. I had it in August, it showed a little bit here and there. Now the MRI/CT scans are clear, I asked about another PSMA scan. The RAD doc said it would show anything, sine my PSA is so low. It can't be measured. I'd like to stay on ADT until there is something that will show up. So he will know what to hit. RAD therapy is nothing to take lightly, the low fiber diet and the weeks of sessions on a hit and miss approach. Not worth it for me right now.

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@philipbrachko No red flags there, Phil; your cancer is still alive and well, just tamped down by the ADT for now.
You don’t want to stay on ADT too long because you run the risk of becoming castrate resistant; that puts you in a whole other ballpark, OK?
Your RO is probably suggesting IMRT to the prostate and pelvic lymph nodes ( DO NOT OMIT THEM!!!). This will deliver a killing blow to the already weakened cancer cells and hopefully destroy them. Not doing radiation is leaving the job only half done - and worse, setting you up for a more resistant strain of cancer. Best,
Phil

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Colleen Young, Connect Director | @colleenyoung | Dec 11, 2025
In reply to @williemac "@spryguy Can you dive deeper into your comment about it being soul crushing? Did you also..." + (show)
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@spryguy Can you dive deeper into your comment about it being soul crushing? Did you also have radiation therapy? How are you doing now?

Thanks

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@williemac, I hope you saw @spryguy's reply to your questions.

Williemac, are you on the same hormone therapy combination -- Zytiga (abiraterone acetate), Prednisone, and Eligard (leuprolide acetate)? How are you doing?

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