My husband's first two rounds of Folfironox created minimal issues. He started having diarrhea after the 3rd round and nausea - impacting his ability to eat and drink. He became dehydrated and spent last night in the hospital getting rehydrated. His dehydration had caused his blood pressure to drop below the low level. This made him light headed and very unsteady on his feet. It sounds like everyone has a different experience on this drug though. My recommendation is to drink tons of liquids and make sure many include electrolytes. I am not a fan of Gaterade due to its very high sugar content. We are currently using Enterade which I buy off the web. Just don't let yourself get dehydrated, it is very easy to get IVs of hydration - probably from your Oncologist's office. It is worth the time to avoid the dangers of dehydration. BTW - with the hydration provided at the hospital - he is feeling ALOT better now and actuallly just ate something.