My side effects were pretty tolerable and I credit getting twice a week acupuncture as well as other meds. Less fatigue and less nausea than expected and almost no neuropathy either during treatment or after treatment. My oncologist and his nurse were very supportive of the acupuncture as there is ample evidence to support its benefit during chemo. I also worked with a naturopath for supplements, cleared through my oncologist, that I also think really helped minimize my side effects. Compazine worked the best for nausea. I did not use cryotherapy. Hope this is helpful. Beth