Hi @vtgal, I already had a hereditary neuropathy when I started letrozole and kisqali at the same time. I get random fleeting pains most commonly in my feet and at night when in the recliner or bed, but I noticed after starting those two meds, the pains hit randomly in other parts of my legs and more frequently. It' really hurts, but it typically only lasts a few seconds to a couple minutes so it's tolerable and I don't take anything for it. I do not know which med is responsible or perhaps both. In my hands I mostly have numbness, but I had that already. I also felt my restless leg syndrome increased after starting those meds. I hope it subsides for you as your body gets more used to the med. Best of luck.