Has anyone used low dose naloxone for pain? arthritis/autoimmune? Can you share your experience, or suggest research links?

My rheumatologist and I are considering using naloxone for my joint and muscle pain. I've been through many Dmards, TNFi biologics, now on a IL inhibitor. The JAK inhibitors may not be a good choice because of my age and heart status.

These are the pain meds that I have taken already:
*I am allergic to NSAIDS, like aspirin, Aleve, Ibuprofen, etc. (First doctor almost killed me with these.)
*Tylenol seems to raise my liver enzymes and doesn't help much with the pain anyway.
*Steroids in normal doses raise my blood pressure, cause headaches and rage.
*For about 8 years, I have used Tramadol in very low doses only for very intense pain. Maybe once every few months. The last 2 times that I used tramadol, it seemed to slow my breathing, scarey.

Medical marijuana is illegal in my state.

Thanks for your help!! I really appreciate any insights.

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