I do not know about kidney failure with azithromycin, but it can affect the heart rhythm in some people. Ethambutol can potentially cause vision loss so it’s important to be checked often by an ophthalmologist while on it. I don’t know what else Rifampin other than it can make tears, sweat, and urine orange. The treatment with these three drugs have made a difference with those with MAC, others with no or few symptoms have opted not to take them.