I do not know about kidney failure with azithromycin, but it can affect the heart rhythm in some people. Ethambutol can potentially cause vision loss so it’s important to be checked often by an ophthalmologist while on it. I don’t know what else Rifampin other than it can make tears, sweat, and urine orange. The treatment with these three drugs have made a difference with those with MAC, others with no or few symptoms have opted not to take them.

I have kidney issues (stage 4) and I am allowed 250 mg azithromycin every other day indefinitely and have been on this for at least 5 months so far with no change in kidney function. (This is a treatment for pseudomonas which is not agreed to by many members of this forum because of the possibility of resistance and other reasons. ) My kidney doctor is very very careful and has not suggested that this is a problem but the dosage is reduced in half from 500 to 250. This is all I can say. It could all be wrong and I am sure there is disagreement but I have to follow some doctor's advice and so far I am doing well.