I have had this for a year, but it came on after covid shots. I learned that I had an intolerance for histamine anywhere in my diet or any topicals that might cause the inflammation. Mast Cell over-reactions are more common than we realize. I went on a low to no, histamine diet……every time I veer from it the inflammation creeps back. I only have it on my face and it turns into little pops on my skin….the mast cell is angry!! But the entire face swells. It was and is diet controlled. It took a lot of study and time to figure out my foods and drinks…..and I’m not complaining as I have my little food group and thats it. The inflammation can make me feel sooooo tired and lethargic as well…..and depressed. So you might deep dive study on this. Beth O’Hara and Becky Campbell have the two most helpful sites on this that I have found, esp for women. I take Dr Campbell’s vitamin line call Optimal Reset to reset my histamine levels and I’ve learned to stay on it, in my case. There is a LOT to learn but so worth it. I got my face back!! Good Luck!