Anyone on Pluvicto (Lu 177), a new drug for prostate cancer?

Posted by dedehans @dedehans, Aug 20, 2022

My close friend has had Pluvecto treatment suggested to him by oncologists. It is relatively new, having been approved by the FDA in March 2022. Have any of you been given this drug? I have read it is radioactive material and patient needs to stay away 6 ft from others for at least 3 days so as not to contaminate them. He has not yet decided whether to take the treatment or not as he is feeling awful enough as is.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

whudup1 | @whudup1 | Apr 11, 2023

Has anyone done treatments with Pluvicto??

Colleen Young, Connect Director | @colleenyoung | Apr 11, 2023

In reply to @whudup1 "Has anyone done treatments with Pluvicto??" + (show)

@whudup1, I moved your question about Pluvicto to this active discussion:
- Anyone on Pluvicto (Lu 177), a new drug for prostate cancer? https://connect.mayoclinic.org/discussion/any-one-on-pluvecto-a-relatively-new-drug/

I encourage you to read previous posts and connect with others like @dlylecpa @robert570 @donalan @leebeth @bamaples @hpete710 and others who have experience with this treatment.

@whudup1, is Pluvicto an option for you?

stonewalker | @stonewalker | Apr 15, 2023

The supply problem with Pluvicto is a real issue. I was scheduled twice and cancelled both times. I am not scheduled for my first dosage on Monday, 4/17/23. I'll keep y'all posted on how I do with it. This site has the most comprehensive information on the Pluvicto that I could find, so thanks for that.
BTW, I am being treated at MD Anderson in Houston.
I'll post again in a few days...

stonewalker | @stonewalker | Apr 18, 2023

I meant to say "now scheduled" in my previous post. Amazing what a single letter can change.
Pluvicto treatment went fine. Technically, no different from the IV Chemo, but I didn't feel as terrible after.
My night last night was no better nor worse than any other recent night, which is good since the IV Chemo for me was horrible. I missed my wife, who slept in a different room per radiation protocol, but I suppose she didn't miss my snoring...
I don't feel badly this morning. Perhaps it is just too soon to see any side effects.
I am hopeful that this will help. The techs told me of a previous guy who needed a catheter to urinate. I'm not at that point, but close enough to empathize. Anyway, just his first Pluvicto treatment allowed him to stop that and go back to normal urination.
On the less good news report, the attending Dr tells me that Pluvicto treatments statistically give us about four months more lifespan than the control group.
Hey, I'll report more later, but hopefully it is as boring as this one.
To all you who suffer from this, and to all your caretakers, my heart goes out to you and may God bless each of you.

melcanada | @melcanada | Apr 19, 2023

https://seer.cancer.gov/statfacts/html/prost.html You can separate by age, race etc

whudup1 | @whudup1 | Apr 19, 2023

Is this It?

stonewalker | @stonewalker | Apr 19, 2023

In reply to @whudup1 "Is this It?" + (show)

That seems to be it. I didn't see the packaging.
Day after the treatment I had some stomach issues. diarrhea included. Extremely tired, which is normal lately, so I don't know if it is related to the Pluvicto.
My stomach seems more settled today, but I am still very tired.

nores717 | @nores717 | Apr 20, 2023

In reply to @whudup1 "Has anyone done treatments with Pluvicto??" + (show)

My husband has had two treatments. While it appears to be helping him, I’m very concerned about the efficacy of this treatment.

digger | @digger | Apr 21, 2023

In reply to @stonewalker "I meant to say "now scheduled" in my previous post. Amazing what a single letter can..." + (show)

Hi sounds good,I heard pluvicto was hard o get that there is a shortage of it I think will be headed to that soon there making a place in N Jersey to make it,but won’t have fda approval till July it comes from Italy

stonewalker | @stonewalker | Apr 24, 2023

I did get my supply from Italy, according to the Dr who administered the Pluvicto. My six treatments are now scheduled out through November at about six week intervals.

I am at seven days after the IV. My first week I was very, very tired. No energy and no interests. Had some stomach issues the first few days, but that leveled out. I can urinate better now than immediately before treatment, so that’s a plus.

FYI, I still have my prostate. My previous Dr did a TURP on me instead of removing the prostate. The TURP is ultimately failing. I guess I heal internally, but I think it was a bad call considering all the issues I have with urination and BM lately. TMI?