Hello! I have bronchiectasis without MAC at this time. My pulmonologist started me on a nebulizer right away. He then advanced me to a Hillrom volara nebulizer and a percussion vest. Since using these I have more production of sputum. Have been following with pulmonology for 3 years now and have had a stable CT since my twice daily nebulizing. Is your doctor a pulmonologist? The nebulizing has been so beneficial to me and I believe has helped to keep my lungs healthy. The side effects of the big 3 seemed pretty harsh. Would weigh that carefully. Is an infectious disease doctor wanting to prescribe those? There people on this forum {especially the mentors} who can give you great insight to the treatment. It"s hard to advise not knowing the severity of how you are feeling but wish you the best of luck.