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PMR and Methotrexate

Polymyalgia Rheumatica (PMR) | Last Active: 1 day ago | Replies (200)
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@sheralee

Have been in a lot of pain. Been off prednisone, but on methytrexate for 2 months with absolutety no help.At wits end.

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Replies to "Have been in a lot of pain. Been off prednisone, but on methytrexate for 2 months..."
John, Volunteer Mentor | @johnbishop | Apr 18, 2023

Welcome @sheralee, So sorry to hear you are struggling with pain. It sounds like you may have tapered off of prednisone too quickly and methotrexate is not providing any pain relief. Have you discussed the continued pain with your rheumatologist or doctor?

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artur | @artur | Apr 19, 2023

Sheralee
Prednisone holds off the immediate pain of PMR disease. My rheumatologist is taking me off prednisone gradually as she increases my methotrexate. Methotrexate takes 3 to 6 months to start working in our systems. When I achieve my max of MXT dosage I should be off the prednisone. This offers the least pain sufferage in tapering off the prednisone, not to mention the immediate pain relief you get from prednisone. Then she will address dropping my MTX dose as my disease declines. Also, with MTX, there is no tapering off of it. Don't like it you can just quit.

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