I haven't experienced any side effects from Actemra. In fact, I would say the side effects from taking prednisone have all improved. Prednisone side effects were the main reason why my rheumatologist wanted me to try Actemra with the hope tapering off prednisone. I'm very pleased about being off prednisone after taking it daily for more than 12 years.

I also have a type inflammatory arthritis that was negative for rheumatoid factor (RF negative). If your husband was diagnosed with PMR and he was also RF positive, then that suggests he may have more than one autoimmune disorder.

My experience with multiple autoimmune disorders made it very difficult for me to taper off prednisone. Fortunately, Actemra seems to work well for all of my problems. I think Actemra would be something worth trying if a rheumatologist recommends it. Having more than one autoimmune problem makes it difficult to find a treatment that works for everything.

I wish you and your husband well.