My PMR is almost six years old. I have tapered off prednisone three times only to have flare ups that required me to go back on the medication. I have been on four different medications (methotrexate, actamera, Xeljanz, and now cosentyx.) They all ceased to work after a certain period of time. Six years ago, I caught my foot while entering my home and ended doing a face plant on my brick steps that resulted in a lot of dental work, a concussion, and whip lash. Four months later, I had PMR. I have no proof that the concussion was the underlying issue, but it sure seems like it was.