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Rising PSA years after radical prostatectomy

Prostate Cancer | Last Active: Mar 5 7:14am | Replies (206)
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@lcashell

I am 63. I was diagnosed April 2018. My doc prescribed all the treatments. Lupron, RP, chemo, & radiation.
The goal, in the Doc’s words, was to have zero PSA. And, for four years it was non-detectable. (>0.01). Success.
In my Doc’s opinion, you can’t produce PSA without a prostate. So IF, PSA becomes detected the cancer has returned.

Which It did this past December. So, I underwent more radiation. And if that doesn’t work they plan to put me back on hormone therapy (most likely Lupron)

In summary, it makes sense to me that if your prostate has been completely removed you should no longer produce PSA. If you still have a prostate, you’re gonna have PSA. If you don’t have a prostate but there is PSA present in your blood, you have cancer somewhere in your body.

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Replies to "I am 63. I was diagnosed April 2018. My doc prescribed all the treatments. Lupron, RP,..."
jrhamp | @jrhamp | Apr 18, 2023

Proton radiation is early 2010 at Loma Linda, an early leader in the utilization of proton radiation therapy. At that time, PSA was 6.7; biopsy indicated cancer on one lobe of the prostate gland. From 2010 until 2016, PSA zero/0; beginning 2017, PSA was noticed at .4. As October 2020, PSA at 2.47.

Question: Does the return of PSA levels positively indicate a return of prostate cancer? As most know, the rule of thumb is anything below PSA of 4 is normal.

At this juncture, I plan to wait alitle longer, then head up the road to Mayo Clinic in Jacksonville, Fl for a review of the options. For example, can another biopsy be done?

Any comments from first hand experience is appreciated.

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