Hello, I had 12 weekly treatments of Taxol, which is notorious for causing neuropathy. I bought chemo ice pack mittens and socks online on Amazon and used them all twelve weeks. I put them on as soon as the Taxol started and tried to use them the entire infusion. They were pretty cold! I transported them in small cooler so they wouldn't melt beforehand. I will say it was a bit miserable, but it worked. I had no neuropathy. My oncologist was impressed; she said most people get something with Taxol, but I did not. I didn't use them after my treatments, only during the infusion.