I have read the article and do understand most of it (I have a public health mycrobiologist background) and I would boil this down to MSM good for what ails us. I am gratified that the studies are catching up to what I have seen in my use with horses and dogs. Even is all you have is osteoarteritis (and who doesn't?), it is a good idea. It doesn't stimulate the immune system in a way that makes our condition worse. Thanks for finding that article. BTW: Anything that down regulates IL6 has got to help us as it seems to be one of cytokines that we make too much of.