I am 83 and a male. I have taken Tamoxifen for 2+ years. I was told by several fellow users to stick with the Mylan brand to avoid night sweats and hot flashes. Great advice! For first few months I was unusually apathetic and had headaches; then decided to "get over it." Some of the response to these estrogen blockers is psychological! I wear support stockings when traveling and stop every 2 hours and walk vigorously for 4-5 minutes (tougher to do on an airplane!). I take it in the morning immediately after breakfast with no GI problems. Be positive and give it a serious try. Good luck.