Hi there, so sorry to hear what you are dealing with! I am in the same boat as @mom23boys , diagnosed stage 4 de nova June 2020 at 54. First line of treatment stopped working after 19 months, the next two didn’t work but as of November 1 I am in a trial with a new med that so far has shrunk the lesions. Aside from 2-3 days feeling lousy the remaining 4 weeks each month I am living my life (almost) normally. Don’t lose hope there are many, many treatment options and new ones coming all the time. Also I agree with whoever said don’t let your tumour markers going up scare you, mine were normal when diagnosed stage 4 and went up later in treatment for an unknown reason and are now normal again. Stay strong, stay hopeful and know that you are not alone in the battle!!!