I had my 3rd Prolia shot in March. I get a Dexascan every year since my osteoporosis is bad. My readings I am telling you are in my spine. I started at a -4.5. I had Reclast for a couple of years and got down to -4.1. After 1 year on Prolia, my spine is -3.6! The only side effect I had was after my third shot and I had some aching in my shoulder blade for about a week. I am not sure I can blame Prolia for that. I have 2 neighbors on Prolia and they claim to have no side effects.