Hot flashes 3 months after Eligard?

Posted by ssaftler @ssaftler, Apr 11, 2023

About 10 days before Christmas, I had a 4-month Eligard injection with 3 weeks of Casodex. I then had BT in February and 23 IMRT treatments starting in March that ended last Wednesday.
Throughout the entire time, I maybe gained about 5 pounds, have been getting up more often at night to urinate, and have had a little more fatigue. I did notice that my alcohol tolerance was zero for a couple months, as was my libido. But that has been the extent of my side effects...
Until the past couple nights, when I woke up around 3AM needing to peel back the covers as I had started to sweat. Each incident lasted about 5 minutes, as I was able to cool off and go back to sleep each time.
My question is whether others here have had such a well documented side effect be this delayed.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

After a 3-month injection of Lupron, I had hot flashes day and night. My face turned noticeably red and I would pick up something, anything, to fan myself.

With some research, I found an article detailing a man my age with prostate cancer, a Lupron injection and hot flashes. His doctor prescribed Venlafaxine, an antidepressant, which relieved the hot flashes.

My PCP switched my antidepressant to Venlafaxine, 37.5 mg 2 times per day. It worked!

Here’s the article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184578/

Good Luck!

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@maxvt

After a 3-month injection of Lupron, I had hot flashes day and night. My face turned noticeably red and I would pick up something, anything, to fan myself.

With some research, I found an article detailing a man my age with prostate cancer, a Lupron injection and hot flashes. His doctor prescribed Venlafaxine, an antidepressant, which relieved the hot flashes.

My PCP switched my antidepressant to Venlafaxine, 37.5 mg 2 times per day. It worked!

Here’s the article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184578/

Good Luck!

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Thanks for the note. Sorry you had the side effects from the start, but happy that you were able to get quick relief.
I was sort of expecting the hot flashes from the outset. However, after the Eligard (alternate drug for Lupron, so I was told) shot, I had no hot flashes or night sweats at all. Nothing after the BT, and nothing through the IMRT treatments. It was only on this Monday and Tuesday mornings that I actually woke up in a sweat. Also noticed my undershirt was damp this morning, but I must have slept right through it. I might not have noticed it if I hadn't had to get up to go to the bathroom (still at least twice per night) around 3AM, since I was dry when I finally woke up.
So, here I am, a full week removed from the last treatment, and now I get the night sweats? I'm expecting a follow-up call from my RO's office today, so I will mention it to them to see if anything can or needs to be done. Perhaps the hot flashes are a side effect of the Eligard wearing off and my testosterone returning to normal?
Hope you are doing well with your therapy or feeling good if you've completed it.

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Hot flashes are due to low testosterone levels. They should be kept at castration levels (less than 50 mg/dL) to keep the cancer under control. I am off Eligard . Still have hot flashes. Reason? My T levels at 21.

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My urologist said to expect hot flashes after starting Eligard and Abiraterone. Somewhat delayed but, sure enough, they occurred. Uncomfortable but tolerable since I otherwise feel good. Energy and stamina levels seem fine for an 82 year old.

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@cesar52

Hot flashes are due to low testosterone levels. They should be kept at castration levels (less than 50 mg/dL) to keep the cancer under control. I am off Eligard . Still have hot flashes. Reason? My T levels at 21.

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I did express my concern to the RO staff yesterday. I was told that the Eligard will still stick around in me until about June, so the T level will remain low and I guess I'll be prone to the hot flashes until the summer, as the level returns to "normal".

My concern was not that I was having them, which I fully expected. It was more of a "why now after all this time" thing.

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