Hi busybeans. I do not know much about the infusions but I don't think you can change your genes. The infusions are probably to improve your ammune system against lung and liver problems. When you think about the mycobacteria that causes MAC, it is in the air and the soil. You would think that anyone that breathes would get MAC. But instead if you do not have alpha-1, but normal genes , you would never know the bacteria had ever been in your lungs because our ammune system was designed by our creator to protect our lungs, therefore it would not become a problem. Anyone with any type of problems with their lungs or liver should be tested for alpha-1 deficiency. Even if anyone who does not have lung or liver problems should be tested as well, even your children. I am not trying to tell anyone how to manage MAC, but for me the Big 3 has not been a good option. I load up on vitamins and mineral supplements, I am trying to not eat foods that causes inflammation and work at keeping my excess mucus clear. My lung doctor is going to run a test on my immune system to see how it can be improved. Do things to reduce stress in your life, stress is never good.