@pmmar1 Welcome to Mayo Connect, and in particular to our very active MAC & Bronchiectasis group. Treating MAC is an ongoing puzzle, as new strains are being identified, with more showing resistance to azithromycin/clarithromycin.

My own primary doc talked about creating "superbugs" over 10 years ago, when it seemed like many providers were prescribing "Z Packs" for every illness (some probably not even bacterial.) She told me Azithromycin is a "big gun" and should be reserved for when the common drugs don't work, but the convenience of the short use had everyone asking for it. Now, here we are with resistant strains. And it happens even when we personally never took the drug.

Can you tell me what your specific concerns are about Cipro?

Also, you tell me that you are newly diagnosed, has your doctor taught you about airway clearance, which is very important to help get the mucus (where the MAC grows) moving and out of your lungs? Many of use use a 7% saline neb to help thin the mucus and get it moving.

Finally, I see that like many of us, your weight is very low for an adult - this is something you need to address, as the effects of long term antibiotic therapy often cause gastro issues and loss of appetite. It might be a good idea to ask your pulmonologist for a consult with a nutritionist who can help you boost your calorie intake while following your preferred diet.

If you wander through the discussions in our group, you will find many helpful tips for coping. I look forward to visiting with you as you adapt to this new "lifestyle."
Sue