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MBC What did you experience when 1st line treatment stopped working?

Breast Cancer | Last Active: Aug 22, 2023 | Replies (27)
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@lisapion77

Hi leann66, your story is so inspirational. I was diagnosed with ER/PR+ HER2- MBC in 2019 at the age of 52. Its crazy how cancer figures out treatments and become resistant to it, as I have experienced it myself. After 3 1/2 years of treatments that at one point put me in NEDS, the tumors managed to become resistant. I am now on Xeloda and will begin my 3rd cycle this coming Friday. So in reading your story, you mention a clinical trial for Daxo-Dxd. What sort of treatment is that? Is it chemo? An infusion? How are you tolerating it?

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Replies to "Hi leann66, your story is so inspirational. I was diagnosed with ER/PR+ HER2- MBC in 2019..."
leeann66 | @leeann66 | Apr 11, 2023

Hello! The full name of the medication is:
https://www.astrazeneca.com/media-centre/press-releases/2022/datopotamab-deruxtecan-based-combinations-show-promising-clinical-activity-in-patients.html
Hope that link works!

It is an infusion every 3 weeks and to get in this trial I have to have had previous lines of treatment that stopped working (which I did). It has been showing good results from what I hear.

My own results are slow but trending positively. Had 8 treatments and cancer has gone/shrunk in breast and lymph nodes, unchanged still in spine and Rob bit that lay take more time - it is not growing though!!!

Let me know if you need more info.

You can contact me directly if you want to chat:
Lclaridge-Marcotte@hotmail.com

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