Good morning, I was diagnosed with ER/PR+ Metastatic Breast Cancer back in 2019. I was immediately put on Ibrance, Letrozole & Lupron Injection. Horrible side effects from the Letrozole and was switched to Exemestane. Gained 20 lbs. and had experienced numbness in hands. I had NEDS in 2020, but it returned in 2021 in the same spot it started (my left breast). At that point, my doctor suggest I have my ovaries removed. Finally? So I took that Lupron injection shot every 30 days to suppress my ovaries and should of had them removed when I was diagnosed in 2019. Why make us go through so much with toxicity, etc. I firmly believe that ANYONE diagnosed with ER positive breast cancer should have their ovaries removed. Of course, that's not the only area in your body to produce hormones, but it will limit it greatly.