Hello,

I take Lupron and a different AI. I adjusted to Lupron quite well. However, I had chemotherapy, which probably helped since it also shuts down your ovaries - so the adjustment to Lupron wasn't quite so bad.

Also, how old are you? I'm 47. My oncologist said the younger you are, the more difficult Lupron is.

In general, my first six months with Lupron and the AI was the most difficult. I did have some muscle soreness, particularly in the mornings. However, I powered through it, exercising every day. I had read in medical journals that the first six months was the worst for side effects. Sure enough, I started to feel better after that time frame, and now, I am much better. My oncologist said it takes time for your body to adjust to new medications. I do still have hot flashes in the evenings and sometimes at night when sleeping.

Tamoxifen works for some people, but not everyone. That's why my doctor suggested Lupron and an AI. It can be somewhat more effective.