Thank you for replying. I was expecting a lot of people who has had MAC to also have Alpha 1. It could be that a lot of MAC patients have never been tested for Alpha 1. I have had two lung doctors, and the Alpha- 1 test is the first thing that they both did on me. According to my lung doctor, the lungs or airways of people with normal genes are protected from bacteria that causes MAC disease. May I ask you if you have every had a fever with the MAC condition?