Lupron Depot: Weakness and instability side effects

I was on lupron for 13 months ( recently taken off and being checked every 3 months) and since taking lupron I have fallen several times while walking and had several occasions of stumbling and recovering but not falling. My recent fall was pretty bad. I have now upped the quality of my walking shoes and I am paying more attention to walking and not falling. However, I am thinking that this new problem may not be related to my 75 years but perhaps the lupron and ADT. If I don’t get better I may just use the exercise bike etc and limit my walking. Any suggestions?

I had some stability deficits before the Lupron but think it got worse. I only had one shot and am hopeful I get some ability to walk without walking sticks but they became essential within about 3 weeks of the shot. That is why I am checking with others on their experience.
I am on a gym about 3 times a week and also swimming 2-3 times a week.
Do you get any tingling in your feet or any numbness?

I am 18 months on Lupron and psa has been less than .1 since beginning injections every 4 months! Post successful robotic prostatectomy by 3 plus years. I am considering stopping injections. Hoping the hormonal side affects subside ( hot flashes reduced strength and no libido sucks but beats alternative) but am worried about PSA level increase. I am 70 years old and walk 2.5 to 3.5 miles per day and chase my 5 year old grandson daily! Ha

You are experiencing a good result from your treatment. I wish the same for me and if I were in your shoes I would not alter a successful treatment plan without the concurrence of your medical team

3 weeks on lupron and 2 weeks radiation-very little side effect thus far...am 77 & walk 4 miles...some light weight action at home...I hate gyms and dont see how a threadmill would help instability problems unless you are walking on some uneven terrain...IF you do not mind the gym scene...do it or whatever works for you BUT do not give up on the workout/walks...I think part of the Lupron ADT deal is a emotional tendancy (sleepiness) to not workout...In my case my body needs it AND watch your carb intake/late night snacking. God Bless. edk

I have experienced the same side effects. No fun! Have fallen a number of times. I have to go very carefully.

Hello there, I am going to offer something to think about. Firstly, I am not a Prostate Cancer Specialist nor do I try to be. I am a Prostate Cancer Patient who underwent a successful Radial Prostatectomy on 10/25/22. I’ve done enough reading and a considerable amount of research on the subject of Prostate Cancer, treatment options, outcomes etc, ( more than most patients)! First and foremost, every patient is an individual with different health backgrounds, risk attitudes, mental, physical, emotional and psychological outlooks on life with personal and family needs. What is true for every patient is that there are absolutely “NO GUARANTEES” about anything when it comes to the treatment protocols and eventual outcomes and results for each patient when it comes to treating their Prostate Cancer.. “CANCER IS NEBULOUS AT BEST, SINISTER AT WORST AND VILLAINOUS IN BETWEEN!”
At best, all you can do is follow the best advice and treatment you can get that best fits your risk attitudes and desired outcomes. For example, due to my HYPOGONADISM existing 11 years before my Prostate Cancer Diagnosis, I was already experiencing a very low level of Testosterone in my body. Coupled with being severely debilitated with Chronic Fatigue Syndrome and Fibromyalgia for the past 30+ years, continuing my “TRT” was a goal of mine following my Radical Prostatectomy. My overall quality of life is dependent upon it. Although some would consider resuming “TRT” after a Radical Prostatectomy somewhat risky etc. My personal situation and prior ongoing total disability for over 30 years reflects a much different overall point of view on my well-being and quality of life moving forward. Thankfully, all of the cancer was in my Prostate, they removed 100% of all the detectable cancer. My PSA has remained at

Philip, you are right, there is no size that fits all. We all do our best and hope and pray for a good and long outlook.

I have been on Lupron for 8 years and I have terrible weakness and fatigue in my thighs. Standing or walking for any length of time is very tiring. As a result, it is very difficult for me to do chores outside the house. Genital shrinking has also been very annoying, but at least my PSA level has remained low, just under 2.0 and the cancer has not metastasized to my bones or any organs although it's in my lymph system. This is surprising, since my Gleason score is 9. So, I don't complain.

My gleason is 9 too, diagnosed 2 years ago. I also have muscle weakness but I am encouraged that you started Lupron 8 years ago and your PSA is still low. It might be time for you to get a helper around the house. Thanks for your post