Anyone who is not using MSM should try it. It really does help with pain and inflammation. Studies show that it down regulates IL6 which is one of our troublesome cytokines. I take 3 grams everyday with juice and have no side effects from it. One morning, I forgot it , and I had such an ache in my shoulders by noon, I had to stop and think what happened. I remembered that I forgot it, then took it and about two hours later the ache was much better. Made a believer out of me. I use the same one I buy for my horses. It works on their arteritis, too and my large animal vet believes in it. It is the real deal.