I agree Eliquis is the least “fussy”. I have AFIB and been on Eliquis for 3 years and no issues. I carry Aspirin in my pocket all the time to take immediately on the onset of an episode because that is what paramedics gave me twice when I called emergency. Even though I have had only 4 episodes in 3 years the constant worry and afraid to exercise was bad for health. Had Cryoablation one week ago and back to normal life. No pain, no discomfort no issues anywhere at all. Absolutely superb, one in a million Electrophysiologist Dr. Archana Ramireddy at Ceders-Sanai.