My cold sensitivity started after the second treatment. Even a cool breeze would affect my face, throat/neck and hands. I wore gloves to take thing out of the refrigerator or freezer. Scarves helped. The sensitivity would disappear before each treatment (usually a couple days before) and nurses would always ask. Dose can be adjusted throughout treatment. It was only towards the end that symptoms lingered. They also continued to worsen for about 6 months after finishing chemo. Best wishes!